neuroscience perspective strengths and weaknesses

Dev. B., et al. For instance, Essex et al. Educational Researcher, November 1989, 18 . 10, 647658. 16, 665675. (2013b). Finally, in the interests of justice, when we recognize that neuroscience is being misused or misrepresented, we must be forthright in communicating this information to finders of fact. Public Interest 6, 57121. Not everyone who wears black has been to a funeral. TMS is a stimulation method that is non-invasive technique. Not only do researchers fail to detect real effects, but of more concern, they may also falsely determine null effects to be real. Functional MRI and PET do not measure brain activity directly, but rather signals that derive from neurovascular correlates of brain activity. Dev. there is an almost literally infinite number of possible interactions between these variables Hum. How is it possible that a person can have a brain defect yet not have symptoms? Sensitivity and specificity can be estimated with small studies, but ascertaining predictive values requires knowledge of prevalence rates of the defect and impairment in the relevant population.41 For the nonspecialist, the basic concept to grasp is that without large surveys of brain structure and function in the general population, we cannot know how many people are walking around with brain imaging anomalies but are functioning normally, because such individuals rarely come to the attention of research studies. Because all known brain areas are involved in multiple processes, knowledge of activity of a single area cannot by itself establish what that brain area was doing at the time. The developing brain: from theory to neuroimaging and back. Socioeconomic status and the developing brain. Considering the opportunities and setbacks mentioned in the previous two sections, we propose a set of main points that require reconsideration and optimized approaches. However, because many brain defects do not result in impairment, neuroimaging alone cannot establish, except in rare cases,42 whether an individual is impaired, or, if impaired, whether the brain defect is the cause. Experience-dependent structural synaptic plasticity in the mammalian brain. Sensitive periods in functional brain development: problems and prospects. One of the main disadvantages of the cognitive psychology is that it refers to a process that we cannot directly observe, as it relies heavily on inference. Rev. Neurosci. In a practical context, the BrainMind Audit Profile (that contains 9 metrics) provides information on the strengths and weaknesses of an individual's brain-and-mind functioning, and by doing . Natl. Dev. doi: 10.1111/cdep.12021, Moffitt, T. E., Arseneault, L., Belsky, D., Dickson, N., Hancox, R. J., Harrington, H. L., et al. These studies provide behavioral information about how experience-expectant processes can be manipulated to occur earlier than expected in a normal developmental trajectory. Thus, incorporating findings that show the time-sensitivity of plasticity into research designs could contribute to revise this way of thinking about human brain development in adverse contexts. The aim of this assignment is to understand Psychological Perspectives and analyse what each perspective's strengths and weaknesses are. qEEG signals have not yet been adequately characterized in the general population, and definitions are needed to distinguish what is a normal or abnormal signal in the first place. Dev. Trends Cogn. Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. We truly live in the golden age of neuroscience. Sci. Neuroscience perspective is the study of the body's functional psychological processes, based on the activities of the neural and structural changes or alterations in the brain. Sci. 46, 156162. However, because the amygdala is active in many other circumstances, it is a reverse-inference error to conclude that amygdala activity necessarily indicates a fearful state. Child Dev. Front. These potentially variable outcomes add another level of complexity to the study of how behavior is modulated by early experiences. 138, 109133. doi: 10.1038/nrn2699, Hubbs-Tait, L., Nation, J. R., Krebs, N. F., and Bellinger, D. C. (2005). Psychobiol. Neurosci. Part of the problem is that neuroscience evidence is genuinely mind boggling. Neurosci. The scientific nature of the approach is one worthy of discussing as it can be both a strength and weakness, as is its reductionist nature. 15:843. doi: 10.1038/ncomms1849, Zhu, X., Wang, F., Hu, H., Sun, X., Kilgard, M. P., Merzenich, M. M., et al. If ADHD is seen as a problem of inhibition, planning and control, then it is logical that tests of general intelligence, which were not designed to measure these cognitive processes (Wasserman . After the accident, Gage's personality was said to have changed as a result of the damage the frontal lobe of his brain. Behavioral evidence is the gold standard for determining functional impairment. Psychol. Sci. Further, even if abnormality could be established, the field currently lacks (with rare exceptions9) adequate studies that correlate qEEG signals with legally relevant functional impairments. Effects of stress throughout the lifespan on the brain, behavior and cognition. Sci. Sci. This means the explanations can be scientifically tested, replicated, and peer-reviewed. Neurosci. I have witnessed neuroscience repeatedly misrepresented and misused. For example, I have found that neuroimaging findings can be useful in directing relevant follow-up neuropsychological testing and bringing attention to important behavioral details that might otherwise have been missed. Neurosci. Strengths and weaknesses of biopsychology research. Strengths and Weaknesses of Humanistic Theory. Dev. Neuroscience has been criticized by some philosophers because the methods and inferences are suspicious of not being logic neither scientific, when relating the brain to the mind, therefore this discipline would not be scientific, at least in the way it has been applied. 53, 371399. 6:277. doi: 10.3389/fnhum.2012.00277, Hackman, D. A., and Farah, M. J. doi: 10.1002/dev.20058, Miller, G. E., and Chen, E. (2013). Leading this research in normal humans are the new techniques of functional brain imaging: positron emission tomography (PET) and magnetic resonance imaging (MRI). Specifically, exposure of different species to enriched conditions, in comparison with either standard or deprived environments, has been associated with several structural changes in neurons and synapses, glial components, brain vasculature, brain cortex weight and thickness, rate of hippocampal cell neurogenesis, availability and metabolism of both neurotrophi factors and neurotransmitters in different brain areas, and neurotrophic and neurotransmitter gene expression (Hirase and Shinohara, 2014). doi: 10.1523/JNEUROSCI.4812-10.2010, Beaver, K. M., Wright, J. P., DeLisi, M., and Vaughn, M. G. (2012). Family-based training program improves brain function, cognition and behavior in lower socioeconomic status preschoolers. 67, 87100. Child Dev. Cognitive psychology--the study of how people think and process information--helps . A dominant cognitive approach evolved, advocating that sensory information is manipulated internally prior to responses made - influenced by, for . There are several known sources of biovariability that make individual predictions of brain impairment devilishly tricky. Received: 27 December 2013; Accepted: 19 January 2015; Published online: 11 February 2015. Since the mid-1990s, researchers have applied neurocognitive behavioral paradigms to compare the performance of children with disparate SES, and technological advances in neuroimaging have allowed for the analysis of neural networks (Hackman and Farah, 2009; Lipina and Colombo, 2009; Hackman et al., 2010; Raizada and Kishiyama, 2010; DAngiulli et al., 2012; Lipina and Posner, 2012; Gianaros and Hackman, 2013). It is certainly true that many studies have identified the amygdalae (there are two of them, one on each side of the brain) as critical processing centers for the experience of fear. Understanding Conciousness: Not definitive proof claustrum is seat of conciousness. doi: 10.1111/j.1529-1006.2005.00024.x, Johnson, M. H. (2005). [13] Sources: Gardner, H., and Hatch, T. Multiple Intelligences Go to School: Educational Implications of the Theory of Multiple Intelligences. At present, the same underlying questions still apply to the analysis of how different rearing environments (i.e., complex vs. standard) modulate brain structure and function at its many different levels (i.e., molecular, genetic, cellular, network, individual, and social-behavior levels, Hirase and Shinohara, 2014). We will also finally get a good sense of the range of what brains in the general population look like and how they change over time. 7, 6773. 6, 817. doi: 10.1037/a0031808, Ganzel, B., Morris, P., and Wethington, E. (2010). Neurosci. When the findings of biology, psychology, and behavioral analysis converge, the argument becomes very convincing. This is not a treatise about theories of knowledge and causation or of neuroscience's challenge to the nature of free will, which have been covered elsewhere.7 Although such philosophical discussions can be fascinating, as noted by others,8 ultimately they distract us from the practical problems that plague neuroscience-based legal claims today. Beyond arachnoid cysts, the inability to make individual predictions is a general problem for any claim that a localized brain defect is responsible for a functional impairment in an individual or that an impairment is caused by a particular brain defect. Hearing ability depends on different degrees of environmental noise exposure (Zhou and Merzenich, 2012), and acoustic enrichment of the environment may promote recovery of auditory cortical processing (Zhu et al., 2014). These limitations are consequences of the group-to-individual inference problem in neuroscience. Neuroscience 247, 117133. The essential neuro claim made by his team was that Mr. Weinstein's arachnoid cyst impaired his rationality. In addition, most of the evidence is limited to cross-sectional or short-term longitudinal designs, which present difficulty for understanding changes in the study of brain development in adverse contexts. doi: 10.1016/j.neuroimage.2009.07.003, Rueda, M. R., Checa, P., and Cmbita, L. M. (2012). (2013). Critical period regulation. Neural correlates of socioeconomic status in the developing human brain. Proc. Developmental cognitive neuroscience is being pulled in new directions by network science and big data. (2010). When positive psychologists advocate a strengths-based approach, I hear it as an important . Transformation of cortical and hippocampal neural circuit by environmental enrichment. Moreover, the consideration of sensitive periods for many processes susceptible to different socioeconomic conditions and timing of intervention requires a revision of the agendas in other disciplines addressing childhood poverty (e.g., many disciplines currently contend that the impacts of economic and social deprivation are permanent and irreversible) (DAngiulli et al., 2012). Brain Res. doi: 10.1016/j.dcn.2011.09.004, Rueda, M. R., Rothbart, M. K., McCandliss, B. D., Saccamanno, L., and Posner, M. I. I discuss two fundamental problems that limit the evidentiary utility of neuroscience-based claims: the problems of reverse inference and group-to-individual inference. In order to understand something it is important to know the history and have a definition. She provides you with an extensive history of complaints and descriptions of functional limitations. All of this should help contribute with the identification and the better comprehension of the mechanisms of mediation of early adversity on brain development. The much that is known about human ways of thinking and behaviors can be attributed to psychological theories. doi: 10.1038/nrn2639, Michel, G. F., and Tayler, A. N. (2005). Disadvantages. (2012). At first glance, this assertion seems reasonable. Genetic differences between individuals can result in widely divergent recruitment of brain areas for similar tasks. In closing, I emphasize that although neuroscience can inform, it will never be able to answer ultimate legal questions of culpability and desert. Generally, this is an error of inference that arises because not all logical inferences are symmetrical. doi: 10.1073/pnas.1010076108, Mohammed, A. H., Zhu, S. W., Darmopil, S., Hjerling-Leffler, J., Ernfors, P., Winblad, B., et al. It is generally accepted now that brain functions are indeed localized (functional specialization18), but only to a certain extent. 33, 1722117231. The problem is biovariability, which limits our ability to predict impairments in individuals despite knowledge of averaged group effects of brain defects. Modern neuropsychological tests are well characterized in terms of specificity, sensitivity, and predictive values. Similarly to many areas of study on the effects of poverty on development, epigenetic analyses of early brain development in humans are in their early stages. Neurosci. ), a physician who recognized physiological psychology in the treatment of illnesses and linked the physical and psychological together. Rev. Front. Strength It has a wide range View the full answer Transcribed image text: Unlike neuropsychological testing, neuroimages are intuitive and concrete (everyone understands that a hole in your head may cause thinking or behavior problems) and naturally command attention because of their novelty, beauty, and associations with scientific authority. I have found that although neuroevidence is rarely dispositive on its own, it can be very useful to direct and support other kinds of evidence, such as neuropsychological testing and old-school behavioral analysis. (2013). More recently, these types of molecular genetic approaches are being increasingly used to examine the association between dopaminergic polymorphisms and educational achievement (e.g., Beaver et al., 2012). Despite the effort it takes and the fraught nature of decision-making in which freedom, life, and treasure hang in the balance, that is the way it should be. (2010) have suggested that properties (i.e., magnitude, duration and chronicity), and types (e.g., social exclusion vs. physical threat) of stressors in early adverse developmental contexts modulate the impact on neural networks involved in acute and chronic responses to stress. U S A 108, 26932698. List of Weaknesses of Cognitive Psychology 1. doi: 10.1016/j.dcn.2010.12.001, DAngiulli, A., Lipina, S. J., and Olesinska, A. Inevitably, however, the curves overlap; some stroke patients will have better impulse control than some healthy controls, and some healthy subjects will have worse impulse control than some stroke patients. Biological psychology has been dated to Avicenna (980-1037 C.E. Vulnerable Child. doi: 10.1111/desc.12087, Shonkoff, J. P., and Bales, S. N. (2011). Dev. Because the brain is such a dynamic organ, one cannot reliably reconstruct from a neuroscan the brain's function at the time of the index event. The study of how adverse environmental conditions (e.g., socioeconomic status (SES) or poverty) influence brain organization and reorganization during development includes different approaches. To do this, we should understand what kinds of questions neuroscience currently can and cannot answer. Nutr. However, Mr. Weinstein agreed to a plea deal of manslaughter, and the matter never went to trial. Overview of Neuroscience Perspective Modern science is highly based on the structural and functional study of the brain. doi: 10.1146/annurev.neuro.27.070203.144327, Hirase, H., and Shinohara, Y. doi: 10.1016/j.dcn.2012.11.009, Essex, M. J., Boyce, W. T., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M., et al. For instance, recently, the topic of stress regulation has been included in the study of poverty and cognitive development through different perspectives, such as vulnerability and environmental susceptibility (Ellis and Boyce, 2011; Hackman et al., 2012; Sheridan et al., 2013), the impact of poverty on executive functions (Blair et al., 2011), and even child development policy (Shonkoff and Bales, 2011). (2005). doi: 10.1016/S0079-6123(02)38074-9, Neville, H., Stevens, C., Pakulak, E., and Bell, T. A. 2d 715 (N.Y. Crim. Am. Socioeconomic status and the brain: mechanistic insights from human and animal research. 1, 101109. This is a fundamental problem in the field and will only improve with better study designs that include larger sample sizes.40. There is also the question of ecological validity: is measuring the brain activity of an individual who is instructed to do nothing for two minutes in a laboratory setting relevant to brain activity during the alleged offense? Impulse control, like any other complex behavior, depends on the function of many brain areas, some of which can compensate for the other if damaged (the concept of neural redundancy29). Adler thought that the basic psychological element of neurosis was a sense of inferiority and that individuals suffering with the symptoms of this phenomenon spent their lives trying to overcome the feelings without ever being in touch with reality (White, 1917) Compensation for Weaknesses The impact of poverty on the development of brain networks. Advances in technology over the past 20 years have given modern neuro-researchers tools of unprecedented power to probe the workings of the most complex machine in the universe (as far as we know). Overall the strengths and the weakness of the research methods adopted by cognitive neuroscientists discussed in my essay (TMS, CAT, PET and FMRI) had a variety of strengths and weaknesses. MaskotOwner/Getty Images. Neurosci. Proc. A strength of the biological approach is that it provides clear predictions, for example, about the effects of neurotransmitters or the behaviors of people who are genetically related. I have found too much weight placed on isolated neurofindings and too little weight on good clinical observation and other kinds of behavioral evidence. To find behavioral evidence that could corroborate or disconfirm the presence of cognitive impairment, the expert examined personal writings, journals, datebooks, calendars, checkbook records, and financial records for a three year period surrounding the time of the offense and concluded this analysis showed no evidence of impairment or change in his management of his everyday affairs (Ref. Of course, these are not the only barriers to CT; rather, they are five that may have the most impact on how one applies CT. 1. doi: 10.1111/j.1467-8624.2010.01538.x, Skoe, E., Krizman, J., and Kraus, N. (2013). In all these approaches, the focus of the analytical efforts was on the analysis of the mechanisms mediating stress responses, which took into consideration a number of guiding principles that could contribute to the understanding of childhood poverty. The aim of this effort is to identify target areas of study that could potentially help build a basic and applied research agenda for the coming years. In this regard, future research should investigate the timing and specificity of neural development that is sensitive to stress exposure (Lupien et al., 2009). The advances in cognitive neuroscience research have posed several conceptual and methodological challenges in the study of childhood poverty. For a hypothetical example, a group of 10 patients with strokes in the orbitofrontal cortex (OFC) is compared with 10 healthy subjects on a test of impulse control and are found to differ on this measure. Differential susceptibility to the environment: toward an understanding of sensitivity to developmental experiences and context. Acad. Enhanced efficiency of the executive attention network after training in preschool children: immediate changes and effects after two months. (2009). Front. Far transfer to language and math of a short software-based gaming intervention. Initial work focused on amygdala activity triggered by threatening and fear-inducing stimuli12 because these kinds of stimuli were widely available and evoked robust findings, thus earning the amygdala the reputation as the fear center of the brain. Without these, qEEG remains unable to distinguish abnormal signals that are simply statistical (e.g., rare but asymptomatic variants) from abnormal signals that imply impairment. Most modern scanners have three Tesla (T) magnets that can resolve brain tissue down to 1 mm (a 1-mm3 block of brain contains approximately 20,000 neurons),57 but the most powerful MRI machine under construction will surpass them all at 11.75 T, which is expected to be able to resolve brain tissue down to 0.1 mm.58 Furthermore, magnetic particle imaging (MPI) promises to increase significantly the resolution of functional MRI by injecting magnetic nanoparticles that act as contrast agents. J. Neurosci. Despite these important advances, the neuroscientific study of human poverty, particularly child poverty, is a topic that has gained attention in the most recent decades. human cognition - came to the fore of psychological thought during the mid twentieth century, overlooking the stimulus-response focus of the behaviourist approach. doi: 10.1097/psy.0b013e3182a5f9c1, Gianaros, P. J., and Manuck, S. B. The presence of brain defects can certainly raise plausible questions of mental impairment, but can only rarely answer them. However, the most pernicious error here, one that is not easy to spot, is the claim that because the amygdala is the fear center, activity there indicates that the defendant was experiencing high levels of fear. The consensus view of modern neuroscience is that the brain accomplishes its tasks by dynamically recruiting networks of interconnected brain modules that combine to process and compute the required solution, a model called distributed processing.19 This model is analogous to the design of computer circuit boards, which contain interconnected specialized chips that combine dynamically in different configurations, depending on the task at hand. Early parental care is important for hippocampal maturation: evidence from brain morphology in humans. Lipina, S. J., and Posner, M. I. Thus, integration of the different forms of plasticity should be the focus for neuroscience research in the field of poverty and brain development aimed at establishing windows for intervention opportunities. Beyond the amygdala, functional imaging studies have demonstrated that generally, brain areas are activated across a very large set of conditions.17 Phrenology, a pseudoscience invented and developed by its founder Joseph Gall in the 18th century, is rightly ridiculed today because of its simplistic one-to-one model that mapped mental functions (secretiveness, mirthfulness) to single points on the brain. In comparison with previous reviews (e.g., Hackman and Farah, 2009; Lipina and Colombo, 2009; Hackman et al., 2010; Raizada and Kishiyama, 2010; Lipina and Posner, 2012), our perspective synthesizes findings, and summarizes both conceptual and methodological contributions, as well as challenges that face current neuroscientific approaches to the study of childhood poverty. Psychopathol. However, it is a dry kind of evidence, abstract and statistical, limiting its persuasive impact. A limitation is that most biological explanations are reductionist. The authors want to thank CONICET, CEMIC, FONCYT, and Fundacin Conectar for their support, their colleagues at the Unidad de Neurobiologa Aplicada, and Jennifer Simonds and Lesa Ellis for proofreading the manuscript and making suggestions that contributed to its enrichment. Neuroimage 49, 11441150. Psychol. 34, 54065415. Another example of the importance of preventive-measuring of neural activity is the study of how the hearing system is affected differently in contrasting socioeconomic contexts (Skoe et al., 2013). Hum. doi: 10.1146/annurev.psych.53.100901.135233, Brito, N. H., and Noble, K. (2014). 1. Neuroscience as a field is driven by our natural fascination with understanding how a physical organ, weighing three pounds and running on 20 watts of power, can give rise to the mind, and with it, our thoughts, feelings, soul, and identity. It is of increasing interest in the courtroom as well, and each year the number of cases using neuroscience-based evidence rises.2 The reasons for this are clear enough. 7, 343348. 5, p 470). In this study, these theories will be . No use, distribution or reproduction is permitted which does not comply with these terms. What are the links between maternal social status, hippocampal function and HPA axis function in children? 84, 5875. Sign In to Email Alerts with your Email Address. Psychoanalysis refers to both a theory and a type of therapy based on the belief that all people possess unconscious thoughts, feelings, desires, and memories. 1923), PET scans advance as tool in insanity defense, Group to individual (G2i) inference in scientific expert testimony, Dynamic neuroplasticity after human prefrontal cortex damage, On the other hand: including left-handers in cognitive neuroscience and neurogenetics, What is cognitive reserve? Socioeconomic status and structural brain development. Front. Individual and combined effects on childrens development. Lipina, S. J., and Colombo, J. The nervous system not only works to produce thoughts, emotions, and behavior, but also controls important body functions, like breathing. Bull. Med. This is especially important since the current neuroscientific evidence on developmental patterns has contributed to our understanding of poverty as a phenomenon much more complex and dynamic than the definitions proposed by other social and human scientific disciplines. For instance, in experiments with infants, different tools are usually introduced to facilitate the acquisition of motor skills before the age at which these behaviors are typically observed (Smith and Thelen, 2003). Because of these known limitations, the American Academy of Neurology and the American Clinical Neurophysiology Society have adopted a position that recommends against the use of qEEG in civil and criminal judicial proceedings,10 although it should be noted that there are proponents of qEEG that dissent from this position.11. The aim of this section is to highlight the contributions made by neuroscientific research, that have allowed the growth and expansion of the field of poverty and brain development in recent years. doi: 10.1038/nrn2897, Hensch, T. K. (2004). doi: 10.1017/s0954579410000635, Pubmed Abstract | Pubmed Full Text | CrossRef Full Text | Google Scholar, Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., and Hensch, T. K. (2010). 82, 1732. Perspect. doi: 10.1097/PSY.0b013e3181e1a23c, Goldin, A. P., Hermida, M. J., Shalom, D. E., Elias Costa, M., Lopez-Rosenfeld, M., Segretin, M. S., et al. Neuroscience and Psychology offer a powerful insight as to what is happening in our brains and those of others. I end by discussing what I believe are genuinely useful applications of neuroscience in the courtroom: as a hypothesis generator and as support for other types of evidence. 6:76. doi: 10.3389/fnhum.2012.00076, Kral, A. Thus, neuroscientific evidence generated during the last decade in the study of childhood poverty has helped to identify the early linguistic environment and the regulation of stress as two main aspects to consider in dealing with the conceptual and methodological challenges, and as future directions in the area. In terms of impacts, mediating mechanisms, hypotheses and the interpretation of data obtained by applying molecular, behavioral, and neuroimaging techniques seems to focus mainly on the comparison of performance and degree of activation rather than the identification of mediating mechanisms (Hackman and Farah, 2009; Lipina and Colombo, 2009; Hackman et al., 2010; Raizada and Kishiyama, 2010; Lipina and Posner, 2012). Furthermore, we must understand the kinds of questions neuroscience will never be able to answer. A bar chart can be generated by a grade schooler on her smartphone, but a functional magnetic resonance image (fMRI), for example, carries with it the imprimatur of big science, as it requires expensive machines and legions of geeks to generate. Psychol. doi: 10.1016/j.neuroscience.2013.05.021. Neuroscience as a field is hindered by underpowered study designs that involve sample sizes that are too small. Strengths and weakness of neuroscientific investigations of childhood poverty: Future directions Authors: Sebastin Javier Lipina Centro de Educacion Medica e Investigaciones Clinicas "Norberto. Allostasis and the human brain: integrating models of stress from the social and life sciences. For such a purpose, it is necessary to encourage the design of interventions and the measurement of outcomes driven by theoretical models to include the consideration of underlying mechanisms at different levels of analysis. It does not allow for direct observation. Perhaps this is inevitable, considering the vast complexity of our brains in comparison to the miniscule amount that we know. Socioeconomic status and child development. It has been proposed that the processes involved in neuroplasticity are affected by different principles (e.g., Mohammed et al., 2002; Hirase and Shinohara, 2014). This analysis is time-consuming and requires methodological innovations for the exploration of molecular pathways, systems and behavioral events, and phenomena simultaneously, and throughout the different stages of development (e.g., Rao et al., 2010). Neurosci. Certain patterns have emerged: speculations clothed as facts, errors of logical reasoning, and hasty conclusions unsupported by evidence and unrestrained by caution. A Frye26-type prehearing was held in which the judge ruled the scans admissible. Although many conceptual and methodological issues should be explored, initial epigenetic findings support the notion that epigenetic changes underlie, at least partially, the long-term impact of early experiences, and that epigenetic alterations are potentially reversible or modifiable through pharmacological or behavioral intervention (Hensch, 2004).

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