Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. Third, the capsule can shorten fever & coughting time. sharing sensitive information, make sure youre on a federal Chest radiographs of the patient. [31]. [1]. Exclusion: studies using two or more Chinese herbal compound as intervention measures will be excluded. Hai Guo, Jin Yang, Jiening Gong, et al. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). In 2017, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (Version 1)(2017) , issued by the National Health and Family Planning Commission Would you like email updates of new search results? If I2 test 50%, a random-effects model will be used for data analysis instead. modify the keyword list to augment your search. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. 7. In China, lianhua qingwen is recommended for treating thepneumonia. The assessment will be adjudicated into 4 levels: high, moderate, low, or very low. Epub 2021 Nov 2. LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by the national Wei Jian administration and the State Administration of traditional Chinese medicine for 20 times. China's top respiratory expert,the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. Bethesda, MD 20894, Web Policies For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. eCollection 2020. Should not be used for wind-cold common cold. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. 2022 Aug;47(16):4505-4516. doi: 10.19540/j.cnki.cjcmm.20220510.501. a non-profit social enterprise that collaborates with other SE producers to build capacity in marketing, sales and operations. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. Wang Y, Zhang D, Du G, et al. The findings of the trial showed strong indications of LHQW in helping patients recover faster and in the prevention of severe covid disease, when compared to the control group using only standard treatment. Delivery takes 2 business days & another 2 calendar days for order processingPROMO OFFER ( completed & over) : Buy 1 Bundle, We Donate 1 Bundle ! HHS Vulnerability Disclosure, Help Statistical heterogeneity will be assessed with the I2 statistic. Stage Food and Drug Administration Approval number:Z20040063. Select all eligible studies published before May 8, 2020. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. [16] The .gov means its official. Please protect from moisture after opening the moisture proof bag. Sofia Tomacruz covers defense and foreign affairs. Preliminary study on the inhibitory effect of three traditional Chinese medicine prescriptions on SARS related coronavirus in vitro [J]. The conclusion of this review will provide evidence to judge whether Lianhua Qingwen combined with Conventional antiviral Western Medicine is an effective and safe intervention for COVID-19. Please try again soon. It is also for prevention of low blood pressure during anesthesia. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. Though no specific drug has been developed so far, emerging agents have been confirmed effective or potentially beneficial to restrain it. Patients with hypertension or heart disease should use with caution, patients with chronic disease such as diabetes, liver disease, kidney disease should take medicine under doctors direction. Chinese drug Lianhua Qingwen is one of 3 treatments which are part of Chinas standard therapy for mild and moderate coronavirus patients. In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission Please try after some time. Novel coronavirus pneumonia treatment plan issued by the national health and Health Committee, State Administration of traditional Chinese medicine (trial version sixth) [EB/OL]. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Hongying Mo, Changwen Ke, Jinping Zheng, et al. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment, MeSH It is not necessary for ethical approval because this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Federal government websites often end in .gov or .mil. We will use the formal test for subgroup interactions in Review Manager 5.3. [4]. Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). Some notable dangerous reactions include heart attacks, strokes, seizures, and sudden deaths. [14]. DC and QZ developed the search strategy. The authors have no conflicts of interest to disclose. For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). Traditional Chinese medicine, such as Lianhua Qingwen, has achieved some curative effect in many countries, but its effect is not clear. government site. [17]. Designed by ACTSmarket. It has important clinical application value to treat patients with covid-19. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. Careers. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). This systemic review will evaluate the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19. [20]. Lianhua Qingwen, which was approved by China Food and Drug Administration (CFDA) in 2004, was the first traditional Chinese medicine that entered the rapid drug approval channel of the CFDA and was used to prevent severe acute respiratory syndrome (SARS). Avoid receiving nourishing Chinese medicine during the period in this product. 2 capsules per dose. V03AX - Other therapeutic products ; Other products with therapeutic properties. We first used Rhubarb to cure the disease, dredge the internal organs and relieve the heat, and then made Huoxiang fragrant and moistening. Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. Individuals w/ cold deficiencies in spleen & stomach or w/ qi. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. Philippines FDA approved LHQW for the treatment of mild Covid-19. Patients diagnosed with COVID-19 of all ages and racial groups will be included. STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. Conclusion: WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Second, CT scan result also shows that patients recover faster than the control group. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. She can be reached atbandiolateresamayb@gmail.com. Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. The site is secure. Sign in to listen to groundbreaking journalism. The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. Keep away from animals and children.This product has not been evaluated by the FDA. 4 capsules per dose. Hypersensitivity to this product should stop usingallergic constitution with caution. BBD Aug 2024. Tips: Please read the directions for use in retail or directed by physician. FOIA Also excluded are studies enrolling <30 participants. > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). The effect of Lianhuaqingwen Capsule on the expression of inflammatory factors and connexin in lipopolysaccharide induced acute lung injury mice [J]. The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. How to take it to realize the maximal efficacy? [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. [4] However, at present, there is no effective antiviral treatment drug confirmed for covid-19. Dosage: 2 capsules twice a day ( after breakfast & dinner). In the analysis, we will exclude lower-quality trials and repeat the meta-analyses to examine whether the quality of included studies influences the pooled results. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. It has become a representative Chinese patent medicine for public health emergencies of the respiratory system. Domingo said this version of the capsule was still unregistered to date, meaning the FDA could not guarantee its quality and safety. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). 10. All tests are 2-tailed, and P < .05 is considered statistically significant. One box of LHQW last 2 days and 4 boxes last 8 days. Wenwen Cui, Xin Jin, Yanfen Zhang, et al. Ahsan W, Javed S, Bratty MA, et al. It is based on the published clinical research literature at present stage. Journal of Guangzhou University of traditional Chinese medicine, 2016 33:5404. This product should be administered strictly in accordance with dosage and administration, and is not for long-term use. For oral use after meals,4 capsules one time and thrice daily. Follow her on Twitter via @sofiatomacruz. LHQW won the 2nd prize of the National Scientific and Technological Progress Award in 2011 for the treatment of influenza. Chinese Journal of experimental pharmacology 2015;21:13943. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. The data extraction form will include the following items: Two reviewers/authors (ZXL and ZQ) will independently evaluate the quality of the included trials through assessing the risk of bias using the following tools, when appropriate: The following aspects of included trials will be assessed: sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, incomplete outcome data, and selective outcome reporting. Receive exclusive coupons and special offers directly to your email inbox. Search for Similar Articles In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. Henan traditional Chinese medicine 2007;27:356. Ding Y, Zeng L, Li R, et al. We may also contact the original authors to provide additional relevant information, if necessary. In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission Also,its packaging is in Chinese characters and needs to comply with FDAs labeling requirements written in English. [Contraindications]Those who are allergic to this product and its ingredients should not take it. may email you for journal alerts and information, but is committed 10 Manufacture address: No.238 Tianshan street, New and high development area, Shijiazhuang, Hebei, China. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment periods. < 5 years: not recommended because it may be difficult for young children to swallow capsules. National Class- A Varieties for Medical Insurance Drugs BMJ 2003;327:55760. Copyright 2023 MIMS Pte Ltd. All rights reserved. Ephedra increases heartbeat and blood pressure. Records from databases and other resources will be uploaded to a database created by EndNote9.7 software. GRADE: an emerging con- sensus on rating quality of evidence and strength of recommendations[J]. This review will be helpful to clinicians treating COVID-19 and asymptomatic infection may provide evidence for researchers. [22]. Clipboard, Search History, and several other advanced features are temporarily unavailable. FREE SHIPPING within SG when you buy 4 boxes or more. Writing review & editing: Xiaolin Zhang. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Below dosage is a guide only. It is to systematically understand the curative effect of Lianhua Qingwen on the treatment of new crown pneumonia, and provide a reference for the design and follow-up work of the Chinese medicine compound Lianhua Qingwen in the global epidemic prevention and clinical trial design and follow-up work. The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. [Functions and Indications] Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. If use with the other drugs at the same time may occur drug interactions,details please consult your physician or pharmacist. Novel coronavirus pneumonia is a new method for the treatment of new crown pneumonia. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. Product PackingEach box contains 24 capsules in blister packing. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. [8]. A park employee (R), seen wearing goggles and face mask, walks in a park in Beijing on March 14, 2020. LHQWG was first used in the treatment of influenza, and studies have found that the drug is superior to oseltamivir in improving the symptoms of influenza A virus infection. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. FDA Director General Eric Domingo likewise confirmed the approval of Lianhua Qingwen in a text message to Rappler on Wednesday afternoon. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. However, there are individual differences in the efficacy of traditional Chinese medicine compound Lianhua Qingwen, which makes the quality of evidence of clinical efficacy of traditional Chinese medicine low. Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and (For Children 4 to 18 years of age): 3 times daily. Used for patterns of heat toxin assailing the lung in flu, manifested as fever, aversion to cold, muscle soreness, stuffy & runny nose, cough, headache, dry & sore throat, reddish tongue, yellow & greasy tongue coating. The Authors. Medicine (Baltimore). A few patients have cough, expectoration, chest distress, dyspnea, muscle ache, diarrhea, and other symptoms. Zhongguo Zhong Yao Za Zhi. Rappler.com. WebFor patients showing mild symptoms, Lianhua Qingwen would be more effective. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. Lu Y, Zhang M, Yang QQ, Li WJ, Yang K, Hu W, Gao SY, Jiang QL, Lin LK, Cheng H, Sun F. Evid Based Complement Alternat Med. Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. V03AX - Other therapeutic products ; Other products with therapeutic properties. Chinese Journal of pharmacology and toxicology 2015;29:2137. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. Cao B, Wang Y, Wen D, et al. Treatment of Pediatric Diseases, 2017, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2016, the Phase II Clinical Trial for Lianhua Qingwen approved by US FDA started in Virginia in the US in September, 2015, recognized as a recommended product in the Expert Consensus Document on Treatment of Cold in Special Populations, 2015, recognized as a recommended product in the Standard Therapy for Middle East Respiratory Syndrome, 2014, recognized as a recommended product in the Standard TCM Therapy for Ebola Virus Infections, 2014, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Expert Consensus Document on Medical Rescuing of Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2012, recognized as a recommended product in the Standard TCM Therapy for Influenza B Virus Infections, 2011, recognized as a recommended product in the Guideline on Diagnosis and Treatment of Influenza, 2010, recognized as a recommended product in the Standard Therapy for Rheumatic Fever (Non-severe Community Acquired Pneumonia), 2009, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Influenza A H1N1, 2008, recognized as a recommended product in the Instructions on Use of TCM Therapies for Prevention and Treatment of Diseases after an Earthquake, 2008, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza (2008), 2005, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza, [Drug Name]Generic name: Lianhua Qingwen Capsules.
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