(2016). doi: 10.1093/annonc/mdx216. Study conception and design: Y-HT and W-FC. 17, 11411145. Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. Incidence and intensity of anaphylaxis/hypersensitivity events: Table: 138P Discontinuations due to anaphylaxis/hypersensitivity were rare for PH IV (generally <1% except two TRYPHAENA arms: 1% and 3%); no discontinuations of PH FDC SC have been recorded so far. Oncol. Haanen JBAG, Carbonnel F, Robert C, Kerr KM, Peters S, Larkin J, Jordan K; ESMO Guidelines Committee. Methods. eCollection 2022. Menu icon A vertical stack of three evenly . Type II hypersensitivity is an IgG or IgM antibody-dependent cytotoxicity in which an antigen attached to cell membranes of red blood cells or platelets binds to an antibody, leading to cell or tissue damage such as haemolytic anaemia or thrombocytopenia. J. Gynecol. | DOI: 10.1097/HS9.0000000000000695. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordanon behalf of the ESMO Guidelines Committee. Monitor. Supportive. doi: 10.1111/IGC.0b013e3181a1bf2e, Ledermann, J. Front. The most commonly exhibited symptom/sign was hypotension (10.7%), followed by anaphylaxis (8.0%) and desaturation (6.7%). PMC Check the latest publications and updates here to make sure you dont miss anything. -, A fatal anaphylactic reaction to paclitaxel is described, which was preceded by a possible delayed reaction to the initial infusion. 8600 Rockville Pike Login to your ESMO accountto sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Oncology 61, 129133. Published in 2020 - Ann Oncol (2020) Authors: M.E. Clin Rev Allergy Immunol. Ann. A cumulative search for anaphylaxis/hypersensitivity (Roche Standard Adverse Event Group Terms) across all pivotal trials cited in the current EMA P IV/PH FDC SC SmPCs. See this image and copyright information in PMC. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Accessibility These patients were provided with intravenous fluid infusion and medications, including corticosteroids, antihistamines, and oxygen application. These ESMO Clinical Practice Guidelines provide recommendations on the prevention/management of dermatological toxicities. official website and that any information you provide is encrypted The site is secure. Carboplatin is among the most commonly used chemotherapeutic agents for ovarian, fallopian tube, and primary peritoneal cancer, as it is active against these types of cancers with usually well-tolerated side effects (Ozols et al., 2003; Parmar et al., 2003; Pfisterer et al., 2006; Pujade-Lauraine et al., 2010). Patients without ovarian cancer were excluded from retrospective analysis of details of hypersensitivity reactions recorded contemperaneously between April 2019 - January 2020 on excel and chemocare (CIS Oncology, Belfast, UK) by the treating practitioner. Only 2 women are Mongolians and the other 733 women are Asian Taiwanese. Carboplatin-related hypersensitivity reactions were defined as symptoms and signs occurring minutes to hours after carboplatin administration. Hypersensitivity reactions associated with platinum-containing antineoplastic agents for thoracic malignancies. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. Oncol. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. The rate of hypersensitivity to carboplatin did not differ by patient age, menopausal status, disease entity, receipt of optimal debulking, or the amount of ascites. Abe, A., Ikawa, H., and Ikawa, S. (2010). 2017 Jul 1;28(suppl_4):iv100-iv118. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Tumori 89, 311313. Monitor. Among the 651 women (88.6%) diagnosed with ovarian cancer, 474 (64.5%) had stage IIIIV disease. Support for third-party writing assistance for this abstract, furnished by Alison McGonagle, PhD, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd., Basel, Switzerland. PDF | On Jul 1, 2017, J B A G Haanen and others published Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Find, read and . National Library of Medicine We also recorded the procedures applied to treat the hypersensitivity reactions and efforts to manage the side effects of carboplatin administration. FOIA Prevention and Management of Dermatological Toxicities Related to Anticancer Agents: ESMO Clinical Practice Guidelines. del Carmen Sancho M, Breslow R, Sloane D, Castells M. Chem Immunol Allergy. It would be worthwhile to design a perspective trial that could randomize patients with carboplatin hypersensitivity to receive an alternative regimen without carboplatin. We also provide recommendations for the continuation of treatment in ovarian cancer patients. In the US, PH FDC SC can be administered by healthcare professionals in patients (pts) homes. Nitipir C, Parosanu A, Popa AM, Cotan H, Olaru M, Iaciu C, Orlov Slavu C. Cureus. Close monitoring is warranted for patients with a history of drug or food allergy, malignant ascites, or cumulative carboplatin dose >4,000 mg. Strategies for preventing carboplatin-related hypersensitivity include reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications. Oncol. Statistical analyses were performed using the Statistical Package of Social Studies (SPSS) version 17.0 (SPSS, Inc., Chicago, IL) and SAS software version 9.4 (SAS Inc, NC, USA) for Windows. Prior to an infusion of a mAb, nurses should do the following (Olsen et al., 2019): . Note: Approved by the ESMO Guidelines Committee: July 2017, last update October 2022. . Oncol. We found a higher incidence of carboplatin-related hypersensitivity among patients with advanced disease (stage IIIIV) with serous carcinoma and malignant ascites. doi: 10.3802/jgo.2013.24.4.342, Confino-Cohen, R., Fishman, A., Altaras, M., and Goldberg, A. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. doi: 10.1006/gyno.1994.1098, Keywords: ovarian cancer, chemotherapy, carboplatin, hypersensitivity, risk factor, Citation: Tai Y-H, Tai Y-J, Hsu H-C, Lee S-P, Chen Y-Y, Chiang Y-C, Chen Y-L, Chen C-A and Cheng W-F (2017) Risk Factors of Hypersensitivity to Carboplatin in Patients with Gynecologic Malignancies. doi: 10.1002/cncr.21168, Dizon, D. S., Sabbatini, P. J., Aghajanian, C., Hensley, M. L., and Spriggs, D. R. (2002). Carboplatin-induced severe hypersensitivity reaction: role of IgE-dependent basophil activation and FcRI. For more detailed information on the cookies we use, please check our Privacy Policy. PMC LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B ). A cumulative carboplatin dose >4,000 mg significantly positively correlated with carboplatin hypersensitivity. All of these reported symptoms and signs occurred within an hour of initiating carboplatin administration. Analysis included treatment cycle, causative drug, severity of reaction as per CTCAE v4 . Read guidelines by topic Latest Guidelines News Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the ESMO events app. Figure 1. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Drafting of manuscript: Y-HT and W-FC. Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses. Gynecol. A sincere thanks to the almost 24,000 participants who attended this year's annual congress! Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V. Clin Pharmacol Drug Dev. These risk factors can help identify patients at greater risk of developing hypersensitivity. are hypersensitivity reactions that are systemic and can be life-threatening (Olsen et al., 2019; Rosell et al., 2017). doi: 10.1006/gyno.2001.6519, Gadducci, A., Tana, R., Teti, G., Zanca, G., Fanucchi, A., and Genazzani, A. R. (2008). This patient developed hypersensitivity reactions during her 23rd cycle of carboplatin administration at a cumulative dose of approximately 14,000 mg. She experienced skin rash, tachycardia, and dyspnea 13 min after starting the infusion. This site uses cookies. The symptoms and signs of the 75 women with carboplatin-related hypersensitivity reactions are given in Table 4. The median patient age was 56 years (range 1694 years). This site uses cookies. Drug Interactions in the Treatment of Malignancy in HIV-Infected Patients. Similarly, a Japanese study found that carboplatin hypersensitivity occurred at a median of 11.5 cycles and 8,084.5 mg (Koshiba et al., 2009). 8:800. doi: 10.3389/fphar.2017.00800. Clinical analysis of thirteen cases of hypersensitivity reactions to carboplatin. This review provides insight into the current knowledge of drug allergy and anaphylaxis to cancer and chronic inflammatory diseases drugs, the mechanisms of drug desensitization and its applications to personalized medicine. Carboplatin hypersensitivity. However, severe carboplatin-related hypersensitivity symptoms can be fatal, as in one of our cases. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Carriers of BRCA genes develop drug allergy after fewer exposures and can present with severe reactions, including anaphylaxis. ESMO is a Swiss-registered not-for-profit organisation. Ke. Gynecol. Close monitoring is warranted for patients with any one of these three risk factors who are receiving carboplatin. Department of Pharmacological and Biomolecular Sciences, Faculty of Pharmacy, University of Milan, Italy, Ospedale Oncologico Armando Businco, Italy, University of Arkansas for Medical Sciences, United States. Unable to load your collection due to an error, Unable to load your delegates due to an error. S.M. The cumulative incidence of carboplatin-related hypersensitivity reactions increased with the number of carboplatin cycles (Figure 1A) and increasing dose (Figure 1B), especially at >8 cycles or a dose >3,500 mg. Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions. (2010) described the use of cisplatin as an alternative to carboplatin. doi: 10.1007/s00280-009-1159-6, Iwamoto, T., Hirai, H., Yamaguchi, N., Kobayashi, N., Sugimoto, H., and Tabata, T. (2014). Int J Mol Sci. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. The dilemma of carboplatin-associated hypersensitivity reactions in ovarian cancer management. ESMO is a Swiss-registered not-for-profit organisation. J. Clin. Front Oncol. Carboplatin and pegylated liposomal doxorubicin (Pujade-Lauraine et al., 2010) or gemcitabine (Pfisterer et al., 2006) led to superior progression-free survival of patients with platinum-sensitive recurrent ovarian cancer compared to paclitaxel and carboplatin. 2017;40(3):120-127. doi: 10.1159/000458443. Morgan C, Tillett T, Braybrooke J, Ajithkumar T. Lancet Oncol. In the present study, 61 patients with carboplatin-related hypersensitivity were rechallenged with carboplatin. The total incidence of carboplatin-related hypersensitivity was 3.21% by the cycle of carboplatin. Severe carboplatin-related hypersensitivity reactions are uncommon. Patients who previously received platinum compounds were excluded. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. The characteristics of the 735 patients are presented in Table 2. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. No use, distribution or reproduction is permitted which does not comply with these terms. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Prevention and Treatment of Side Effects of Immunotherapy for Bladder Cancer. The ESMOClinical Practice Guidelines(CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings ofevidence-based medicine. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. Reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications are especially important for patients at high risk of carboplatin hypersensitivity to detect the hypersensitivity early and avoid severe hypersensitivity without compromising the efficacy of the antineoplastic regimen. Desensitization for hypersensitivity reactions to medications. All accepted abstracts are available in theESMO 2017 Abstract Book. II., Markman, M., Brown, J., et al. Successful carboplatin desensitization in patients with proven carboplatin allergy. We also found higher rates of hypersensitivity among patients with malignant ascites compared to patients without malignant ascites (P = 0.009, chi-squared test), and in patients who had experienced allergic reactions to other medications or food (e.g., paclitaxel, penicillin, aspirin) compared to patients who had not experienced previous allergic reactions (P < 0.001, chi-squared test). J. Rosell S, Blasco I, Garca Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. (2009). Front Oncol. Cancer. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Assess for pustules or blisters or erosions in addition to areas of "dusky erythema" which may feel painful to palpation. The ESMO 2017 Congress, in partnership with the European Association for Cancer Research (EACR), created an environment where cancer researchers and clinicians came together to collaborate and exchange ideas. The ESMO guideline recommends patients receive surveillance by colonoscopy every 3 years beginning at age 25 for MLH1 and MSH2 mutation carriers and age 35 for MSH6 and PMS2 mutation carriers, or . A video magazine about the congress, highlighting the most important information about the event. A., Colombo, N., du Bois, A., Delaloye, J. F., Kristensen, G. B., et al. The comparison between other countries and ours about characteristics of the patients receiving carboplatin-based chemotherapy and risk factors of carboplatin-related hypersensitivity reactions. (2003). (2003). 329 (152 CPI-treated v 177 CPI-nave, including 60 tx-nave) pts with RET fusion+ NSCLC were analyzed. Analysis and interpretation of data: Y-HT, Y-JT, H-CH, Y-YC, and W-FC. Have a look to the ESMO 2017 Programme online! We assessed occurrence, incidence and severity of these events in key Roche clinical trials of PH IV/PH FDC SC, and did a timetrend analysis (by cycle) for metastatic BC (MBC) and early BC (EBC) studies. (1994). HHS Vulnerability Disclosure, Help (2005). 8600 Rockville Pike 84, 378382. Gynecol. There was a striking difference in PFSmedian 16.8 versus 5.6 months, HR 0.52 (highly significant)with the difference in PFS sustained at 12- and 18-month landmarks. Chan. The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B). (2003). 66, 265267. Supporting your clinical decisions with ESMOs regularly updated Clinical Practice Guidelines and consensus recommendations, developed by the leading experts in our profession. Int. 21, 31943200. Upon the occurrence of symptoms and signs, carboplatin infusion was immediately stopped. The rate of hypersensitivity was significantly higher among patients with advanced stage disease (IIIIV) compared to patients with early stage disease (III) (P < 0.001, Kruskal-Wallis test), and among patients with serous or mixed histological type compared to patients with other histological types (P = 0.003, Kruskal-Wallis test). Za. Disclaimer. J Oncol Pract. Characteristics of the 735 women receiving carboplatin-based chemotherapy. During the study period, our institution applied carboplatin (including carboplatin with cyclophosphamide or paclitaxel) as the front-line chemotherapy for women with ovarian, fallopian tube, and primary peritoneal cancer. Paclitaxel plus platinum-based chemotherapy vs. conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Vaccines (Basel). Table 5. Life expectancy for cancer patients allergic and desensitized to carboplatin and non-allergic to, MeSH Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Incidence and intensity of anaphylaxis/hypersensitivity events: Table: 138P. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. 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